Lesson 1 Build a Better World
Two Heroes Who Fought a Deadly Disease
One evening in late November 1932, a bitterly cold wind blows fiercely as two figures ____ from a laboratory.
Darkness begins to fall as they ____ out into a world of failed banks, collapsed industry, and widespread despair—a world ruined by three years of the Great Depression.
The workday has come to an end, but for Pearl ____ and Grace Eldering, a different kind of work is about to begin.
They are on their way to visit the homes of children suffering from a ____ disease called pertussis.
The two women go from ____ to home collecting samples from the sick children by the faint light of their lamps.
They listen to the tragic stories of desperate and unemployed parents as the children, coughing uncontrollably and struggling to breathe, barely ____ on to life.
Pertussis is a bacterial disease characterized by serious coughing, breathing ____, and the high-pitched “whooping” sound that people with the disease make as they try to breathe in.
Because of this ____ sound, people started to call the disease “whooping cough.”
For a long time, this terrible illness was ____ of the greatest terrors of families with young children, because babies who contracted it had a high chance of dying.
In the 1930s, an average of 6,000 people died of whooping cough in the ____ States each year.
Ninety-five percent of them were children under ____ years of age.
The cause of the disease had been identified in 1906, but the ____ that had been developed were ineffective.
Scientists and researchers worked for more than 20 years to ____ an effective one, but their efforts were fruitless — until Kendrick and Eldering came along.
Pearl Kendrick studied bacteriology
Pearl Kendrick studied ____ in university and was recruited by the Michigan Department of Health in 1920.
It was there that she met fellow bacteriologist ____ Eldering.
The ____ quickly bonded, and in 1932 they started working together on a vaccine for whooping cough.
Personal ____ served as motivation for both of them, as they had each survived whooping cough as children themselves and remembered the severe pain of the disease.
Both scientists were ____ eager to promote children’s health.
Unfortunately, research ____ was extremely limited due to the Great Depression.
Also, ____ and Eldering had to develop the vaccine as a side project.
It was like having a second job for which they never received any ____.
Still, when they finished their ____ duties each day, they would get started on the work that they were enthusiastic about.
The difficulties they faced did not stop them from persisting ____ their goal.
They did not do the work to make extra money; instead, they worked to relieve the suffering of innocent ____ and their families.
They began the process of developing their vaccine by gathering ____ of the bacteria that cause whooping cough.
To support them, ____ doctors and nurses provided “cough plates” from their patients.
The patients coughed onto a petri ____, which was then put into an incubator.
This allowed the bacteria to grow into colonies that Kendrick and Eldering could ____.
____ they collected samples on their own, they would go to the homes of sick children.
Each time, they were reminded once again of the dreadful suffering ____ by the disease.
The ____ of these innocent young victims coughing and struggling to breathe was a powerful reminder of the urgent need for an effective vaccine.
Kendrick and Eldering spent many long nights
Kendrick and Eldering spent many long nights studying the ____ and finally produced a potential vaccine.
Before they performed ____ clinical trials, though, they had to be certain that it would not have any negative side effects on the subjects.
They ran many laboratory tests, and they even injected it into ____ to confirm that it was safe.
From 1934 to 1935, they conducted their first field ____ with 1,592 children.
In the group of 712 vaccinated children, only four developed ____ cough, and none of these cases were serious.
Despite the apparent success of the vaccine, Kendrick and Eldering wanted further confirmation of ____ effectiveness.
They ____ determined to expand their research and run more tests with larger groups of children.
____, they were unable to proceed because they were facing a severe lack of funds.
With ____ of children continuing to suffer from the disease, they found themselves in a desperate situation.
Luckily, they got help from an ____ figure.
In 1936, First Lady Eleanor Roosevelt herself visited the laboratory and saw with her own eyes the efforts that Kendrick and Eldering were making in their ____ against whooping cough.
____ Roosevelt, whose husband suffered from polio, was interested in fighting infectious diseases.
She spent time with the women and ____ to realize the enormous importance of their work.
With her help, Kendrick and Eldering were able to secure ____ funding to conduct a large-scale trial.
By 1937
By 1937, Kendrick and ____ were able to include more than 4,200 children in their trial.
Just as in their first field test, the vaccinated group demonstrated a high ____ of immunity against the disease.
The scientific community was ____ at the results, and, in 1940, the vaccine started being distributed all across the United States.
Four years ____, it was added to the American Medical Association’s list of recommended immunizations, and soon after, there was a dramatic decline in whooping cough infections.
In the mid-1970s, the number of annual deaths caused by ____ cough, which had reached 7,518 in 1934, dropped to under 10.
Kendrick and Eldering were often told that they could have become very wealthy if they had ____ their vaccine.
However, they replied that it had ____ been created by them alone, but with the help of many others.
They also avoided personal interviews, not wanting to reveal the great ____ they had made.
They said that they had genuinely enjoyed the challenge of creating the vaccine, so the ____ praise that they received made them uncomfortable.
In the end, knowing that so many lives were being ____ thanks to their hard work was enough of a reward for these remarkable and modest heroes.